Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.
The dynamic assembly of filamentous (F) actin plays essential roles in the assembly of presynaptic boutons, the fusion, mobilization and recycling of synaptic vesicles (SVs), and presynaptic forms of plasticity.However, the molecular mechanisms that regulate the temporal and spatial assembly of presynaptic F-actin remain largely redken shades 9gi u